Mesterolon is often used as an antiestrogenic treatment and may be
used by those who have had a poor reaction to testosteron
treatments. The drug has shown to be beneficial in treating sexual
dysfunction, impotency and low libido. Mesterolon binds to estrogen
receptors, reducing their activity, which not only reduces estrogen
production, but also encourages natural testosteron production in
Proviron on its own is considered to be a weak steroid according to
a study by A.T. Kicman published in the British Journal of
Pharmacology. However, it has unique properties that make it a
useful and effective enhancer, especially of testosterone. In
normal levels in the body, testosterone is mostly inactive because
most of it is bound by sex hormone binding globulin (SHBG) and
albumin. Proviron also has a great affinity for SHBG, so when
administered, it will bind to the SHBG, leaving more testosterone
Increase Muscle Density:
The increase in free testosterone can then mediate anabolic
activities, including protein synthesis, which in turn increases
Estrogen is only active and effective when bound to estrogen
receptors. Proviron decreases the ability of these estrogen
receptors, found in the muslces, to bind to estrogen, therefore
decreasing the amount of active estrogen. In addition, Proviron has
an affinity for the aromatase enzyme, which is the enzyme in the
body that binds with testosterone and converts it to estrogen. When
Proviron binds to the enzyme, it blocks testosterone from binding,
therefore reducing the amount of estrogen produced. These effects
result in a decrease in water buildup in the body, which gives the
muscles a leaner, harder look.
Impotence, also referred to as erectile dysfunction, is the
inability to achieve or maintain an erection. One of the causes of
impotence is a low level of testosterone. Proviron, as dicussed in
the section above, has the ability to enhance testosterone, which
can then relieve the symptoms of impotence.
Male infertility, or sub-fertility, is often caused by a problem
with the production of sperm. Although the full mechanism of male
fertility is not yet understood, it is known that the production of
sperm is dependent upon both androgens (like testosterone) and
gonadotrophins which are the hormones that stimulate the sexual
organs. Androgens have been used to treat infertility problems, but
they often decrease gonadotropin secretion, making it ineffective
for inducing sperm production.
Proviron stimulates androgens while having little to no effect on
the gonadotrophins, according to a study conducted by Patrick Bye
and published in the Postgraduate Medical Journal. Proviron,
therefore, is a desirable candidate to treat some male infertility
and more studies continue to be conducted.
Mesterolone is uesd for treating male hypogonadism and reducing
Mesterolone is helpful in stacks because of its unique ability to
keep the body from turning testosterone into estrogen, thus giving
the testosterone a better anabolic effect.
Also, It can help boost the potency of testosterone in the body by
freeing testosterone from its binding to sex hormone-binding
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